Improved bioavailability of cromolyn sodium using inhaled PA101 delivered via eFlow® nebulizer
نویسندگان
چکیده
منابع مشابه
[Distribution of inhaled aerosol using nasal nebulizer].
In this paper, we examined distribution and deposition of inhaled 99mTc aerosols in human respiratory tract, nebulization equipment and expired aerosols. Jet nebulizers were used and aerosols were inhaled through the nose. Results were as follows: 1. On normal breathing, deposition rate of human respiratory tracts in normal subjects were 22% of total dosage and there was no difference from sinu...
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The Respigard II nebulizer system is the approved method to deliver pentamidine aerosols in the USA. Although continuous operation of the nebulizer until dryness is a designated regimen, the actual pentamidine dose delivered under the operating condition has not been thoroughly studied. Pentamidine solutions (300 mg in 6 mL water) were nebulized continuously with the Respigard II nebulizer syst...
متن کاملEffects of cromolyn sodium on isolated rat's trachea
Cromolyn sodium (cromolyn) effectively inhibits both antigen- and exercise-induced asthma when used as an aerosol. Intranasal cromolyn is also recommended for preventing and treating allergic rhinitis. By inhibiting the degranulation of sensitized mast cells, cromolyn reduces the release of mediators that trigger inflammation and the allergic response. The precise pharmacologic activity of crom...
متن کاملCorticosteroids and cromolyn sodium as modulators of airway inflammation.
Heightened airway reactivity is a cardinal feature of asthma and correlates with many clinical features of the illness, such as the acute response to bronchodilator drugs, the magnitude of diurnal fluctuations in lung function, and the amount of therapy required to control symptoms. Data have accumulated indicating that a reduction in airway reactivity can decrease asthma morbidity, and many ad...
متن کاملDouble blind crossover study of cromolyn sodium inhibition of aerosol antigen challenge.
Six men patients, with type I hypersensitivity to pollen antigens, were studied during four separate periods approximately one week apart. During the first and fourth periods, aqueous extracts of ragweed or grass pollen were administered via a nebulizer. During the second and third periods the patients were treated with a single capsule of cromolyn sodium or placebo in a double blind fashion, d...
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ژورنال
عنوان ژورنال: European Clinical Respiratory Journal
سال: 2020
ISSN: 2001-8525
DOI: 10.1080/20018525.2020.1809083